This instruction implements AFPD 11–2, Flight Rules and Procedures, by prescribing guidance and procedures to inform base support elements of arriving or departing aircraft carrying hazardous cargo. It specifies the special procedures that apply to aircraft carrying nuclear, chemical, or biological research materials. It lists actions to be taken by aircraft commanders, aircrew members, and technical escorts during in-flight emergencies that involve such materials. It applies to nuclear cargo, toxic chemical ammunition, highly toxic substances, hazard division 1. 1 through 1.3 explosives, and infectious substances (including biological and etiological materials). In addition, it applies to Class 7 (radio active materials) which require a yellow III label, inert materials, and all other hazard classes or divisions, except class 9 and Other Regulated Material, when shipped in quantities of 1,000 pounds or more aggregate gross weight.